|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5662604||1407574||2017||5 صفحه PDF||سفارش دهید||دانلود کنید|
BackgroundNeuropsychiatric symptoms (NPS) are common in Alzheimer's disease (AD) and are associated with admission to institutional care. Current guidelines recommend non-pharmacological interventions as the first-line treatment for NPS. However, high-quality randomized studies focused on NPS are scarce. The objective here was to examine whether a regular and long-term exercise programme either at home or as a group-based exercise at an adult day care centre has beneficial effects on AD patients' NPS or permanent institutionalizations.Design, setting, and participantsA randomized, controlled trial with 210 community-dwelling AD patients.InterventionTwo types of intervention comprising (1) group-based exercise in day care centres (GE) and (2) tailored home-based exercise (HE), both twice a week for 12Â months, were compared with (3) a control group (CG) receiving usual community care.MeasurementsNPS were measured with the Neuropsychiatric Inventory (NPI) at baseline and 6 months, and depression with the Cornell Scale for Depression in Dementia (CSDD) at baseline and 12Â months. Data on institutionalizations were retrieved from central registers.ResultsNo significant differences between the groups were detected in NPI at 6Â months or in CSDD at 12Â months when analyses were adjusted for age, sex, baseline Clinical Dementia Rating, and Functional Independence Measure. There was no difference in admissions to permanent institutional care between the groups.ConclusionsRegular, long-term exercise intervention did not decrease NPS in patients with AD.
Journal: European Geriatric Medicine - Volume 8, Issue 2, April 2017, Pages 153-157