کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5662728 1590495 2017 5 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
New Therapeutic Targets in Alzheimer's Disease
ترجمه فارسی عنوان
اهداف جدید درمانی در بیماری آلزایمر
کلمات کلیدی
بیماری آلزایمر؛ آمیلوئید؛ پروتئین تاو؛
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب سالمندان و علم پیری شناسی
چکیده انگلیسی

SummaryUp to the present, the identification of neurochemical alterations underlying Alzheimer's disease allowed for the development of the first generation of therapies that are somewhat specific for this disorder. Although both cholinesterase inhibitors and NMDA receptor blockade have well-proven efficacy levels, the clinical outcomes of patients receiving such treatments are rather limited; with many authors considering them as “symptomatic” treatments. In this context, it is safe to say that although the microscopic alterations present in AD have been well known for over a century, we have failed to identify therapeutic agents able to block the synthesis and aggregation of amyloid β42 or the formation of neurofibrillary tangles. Some new therapeutic strategies have however been explored in the last few years. This paper aimed at reviewing the evidence supporting these new “disease modifying” therapeutic options, including anti-amyloid and anti-Tau strategies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Gerontology - Volume 11, Issue 1, March 2017, Pages 2-6
نویسندگان
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