کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5662732 1590495 2017 5 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
cIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck
ترجمه فارسی عنوان
افزایش بیان cIAP-2 در بیماران سالمند مبتلا به سرطان سلول سنگفرشی سر و گردن
کلمات کلیدی
cIAP-2؛ کارسینوم سلول سنگفرشی سر و گردن
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب سالمندان و علم پیری شناسی
چکیده انگلیسی

SummaryBackgroundEvidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN).MethodsImmunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0-3) and statistical association with clinical-pathological factors was determined.ResultsHigh expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age ≥60 were significantly associated with worse survival in univariate analysis, but only an age ≥60, and not cIAP-2 expression, was prognostic in multivariate analysis.ConclusionHigh expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical-pathologic factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Gerontology - Volume 11, Issue 1, March 2017, Pages 22-26
نویسندگان
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