|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5662732||1407581||2017||5 صفحه PDF||سفارش دهید||دانلود کنید|
SummaryBackgroundEvidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN).MethodsImmunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0-3) and statistical association with clinical-pathological factors was determined.ResultsHigh expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age â¥60 were significantly associated with worse survival in univariate analysis, but only an age â¥60, and not cIAP-2 expression, was prognostic in multivariate analysis.ConclusionHigh expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical-pathologic factors.
Journal: International Journal of Gerontology - Volume 11, Issue 1, March 2017, Pages 22-26open access