کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5664063 1590703 2017 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Drug resistance in pancreatic cancer: Impact of altered energy metabolism
ترجمه فارسی عنوان
مقاومت به مواد مخدر در سرطان پانکراس: تاثیر متابولیسم انرژی تغییر یافته
کلمات کلیدی
متابولیسم سرطان، مقاومت در برابر مواد مخدر، عوامل جدید متابولیک هدف، سرطان پانکراس،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی

Pancreatic cancer is a highly deadly disease: almost all patients develop metastases and conventional treatments have little impact on survival. Therapeutically, this tumor is poorly responsive, largely due to drug resistance. Accumulating evidence suggest that this chemoresistance is intimately linked to specific metabolic aberrations of pancreatic cancer cells, notably an increased use of glucose and the amino acid glutamine fueling anabolic processes. Altered metabolism contributes also to modulation of apoptosis, angiogenesis and drug targets, conferring a resistant phenotype. As a modality to overcome chemoresistance, a variety of experimental compounds inhibiting key metabolic pathways emerged as a promising approach to potentiate the standard treatments for pancreatic cancer in preclinical studies. These results warrant confirmation in clinical trials. Thus, this review summarizes the impact of metabolic aberrations from the perspective of drug resistance and discusses possible novel applications of metabolic inhibition for the development of more effective drugs against pancreatic cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 114, June 2017, Pages 139-152
نویسندگان
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