کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5665223 1407738 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spinal dorsal horn astrocytes: New players in chronic itch
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
پیش نمایش صفحه اول مقاله
Spinal dorsal horn astrocytes: New players in chronic itch
چکیده انگلیسی

Chronic itch is a debilitating symptom of inflammatory skin conditions, such as atopic dermatitis, and systemic diseases, for which existing treatment is largely ineffective. Recent studies have revealed the selective neuronal pathways that are involved in itch sensations; however, the mechanisms by which itch turns into a pathological chronic state are poorly understood. Recent advances in our understanding of the mechanisms producing chronic itch have been made by defining causal roles for astrocytes in the spinal dorsal horn in mouse models of chronic itch including atopic dermatitis. Understanding the key roles of astrocytes may provide us with exciting insights into the mechanisms for itch chronicity and lead to a previously unrecognized target for treating chronic itch.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Allergology International - Volume 66, Issue 1, January 2017, Pages 31-35
نویسندگان
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