کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5665877 1407775 2017 3 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Rapid assessment of tetanus vaccine-induced immunity in Bangladesh and the Gambia
کلمات کلیدی
GVAP; Global Vaccine Action Plan; DTP3; diphtheria-tetanus-pertussis; rFragC; recombinant Fragment C; FN; false negatives; TP; true positives; IQR; inter quartile range; Vaccine; Tetanus; Dipstick; Lateral flow; Fragment C;
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Rapid assessment of tetanus vaccine-induced immunity in Bangladesh and the Gambia
چکیده انگلیسی

•Point of care evaluation of vaccine-induced anti-tetanus antibodies•No cold chain requirement•Two dipsticks optimized either for testing serum or blood•The devices were tested at two field sites: icddr,b, Bangladesh and MRC Keneba, The Gambia•The dipsticks compared favorably with the results from a commercial ELISA

We have developed recombinant fragment C based rapid point of care dipstick devices to assess tetanus immunization status using plasma or whole blood. The devices demonstrated specificity of 0.90 and sensitivity of 0.90 (whole blood)/0.94 (plasma) at field sites in Bangladesh and The Gambia when compared to a commercial ELISA with the immune cut-off titer set as ≥0.1 IU/mL.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 87, Issue 3, March 2017, Pages 272-274
نویسندگان
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