کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5665897 1407776 2017 3 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Synergistic activity of ceftazidime-avibactam and aztreonam against serine and metallo-β-lactamase-producing gram-negative pathogens☆☆☆★
کلمات کلیدی
Aztreonam; Ceftazidime; Avibactam; Synergy; Etest; beta-Lactamase; Carbapenemase;
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Synergistic activity of ceftazidime-avibactam and aztreonam against serine and metallo-β-lactamase-producing gram-negative pathogens☆☆☆★
چکیده انگلیسی

•The in vitro synergy between ceftazidime, aztreonam, and ceftazidime-avibactam was assessed against 7 serine and metallo-β-lactamase producing pathogens•Aztreonam and ceftazidime-avibactam were synergistic against metallo-β-lactamase-producing Enterobacteriaceae spp.•None of the combinations tested were consistently synergistic against IMP-producing Pseudomonas aeruginosa.•The Etest MIC:MIC ratio method may be clinically practical for assessing synergy.

This study assessed the in vitro synergy between ceftazidime, aztreonam, and ceftazidime-avibactam against serine and metallo-β-lactamase (MBL)-producing pathogens via the Etest MIC:MIC ratio and Agar-Etest synergy methods. The combination of aztreonam and ceftazidime-avibactam was synergistic against all Enterobacteriaceae. None of the tested combinations were consistently synergistic against IMP-producing P. aeruginosa.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 88, Issue 4, August 2017, Pages 352-354
نویسندگان
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