کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5665906 | 1407777 | 2017 | 6 صفحه PDF | دانلود رایگان |
- A commercially available test for rapid serodiagnosis of cystic echinococcosis
- A retrospective cohort assessed test performance and cross-reactivity
- A prospective cohort assessed the test in routine laboratory conditions
- Test performances are similar to other serological tests.
Cystic echinococcosis (CE) is a neglected zoonotic disease, diagnosed through clinical findings, imaging techniques, and serology, for which many serological tests are available. Here we report a rapid unit assay, the immunochromatographic VIRapid® HYDATIDOSIS test (Vircell, Granada, Spain), potentially suitable for laboratories in low-prevalence or poorly equipped areas. This test was evaluated with a large retrospective cohort (224 sera), including patients suffering from CE or from other parasitic or liver diseases. The test was also assessed in routine conditions with a prospective cohort (115 sera) in areas where both cystic and alveolar echinococcoses have been diagnosed. Its performance (in terms of sensitivity, specificity, and both positive and negative likelihood ratios) was similar to an ELISA based on a crude antigen. Our study shows that this test performs adequately in the diagnostic process, when used with caution, especially regarding cross-reactivity with other parasitic diseases.
Journal: Diagnostic Microbiology and Infectious Disease - Volume 89, Issue 1, September 2017, Pages 20-25