کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5666007 | 1407781 | 2016 | 4 صفحه PDF | دانلود رایگان |
- Nasal swab MRSA PCR and respiratory culture concordance was validated in 200 patients with pneumonia.
- The nasal swab MRSA PCR test demonstrated 90.5% sensitivity and 79.9% specificity.
- The positive and negative predictive values were 34.5% and 98.6%, respectively.
- 300/782 combined days of anti-MRSA therapy were considered potentially preventable.
- The nasal swab MRSA PCR may guide discontinuation of anti-MRSA therapy in pneumonia.
This retrospective study aimed to validate the concordance between nasal swab methicillin-resistant Staphylococcus aureus (MRSA) polymerase chain reaction (PCR) test and respiratory culture and to determine the number of potentially preventable days of anti-MRSA therapy in patients with pneumonia. Two hundred adult inpatients in the intensive and intermediate care units were included. The nasal swab MRSA PCR test was positive in 55 (27.5%) patients. MRSA was isolated from respiratory culture in 21 (10.5%) patients. The nasal swab MRSA PCR test demonstrated 90.5% sensitivity, 79.9% specificity, 34.5% positive predictive value, and 98.6% negative predictive value. Anti-MRSA therapy was initiated in 168 (84%) patients. Patients in the study received a combined 782Â days of anti-MRSA therapy; 300Â days were considered potentially preventable. This study suggests that the nasal swab MRSA PCR test may be used to guide discontinuation of anti-MRSA antibiotics in patients with clinically confirmed pneumonia in the intensive or intermediate care units.
Journal: Diagnostic Microbiology and Infectious Disease - Volume 86, Issue 3, November 2016, Pages 307-310