کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5666345 1591375 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between the killer cell immunoglobulin-like receptor a haplotype and childhood acute lymphoblastic leukemia
ترجمه فارسی عنوان
ارتباط بین گیرنده ی ایمونوگلوبولین مشابه سلول قاتل، یک هپلوتیپ و لوسمی لنفوبلاستی حاد دوران کودکی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی

Killer immunoglobulin-like receptors (KIRs) have the ability to regulate natural killer (NK) cell function through inhibition/activation mechanisms. Healthy human cells express HLA class I ligands on their surface, which are recognized by NK cells to avoid spontaneous cell destruction. The associations of KIRs and/or HLA class 1 ligands in leukemic patients have been studied in some populations, with some of these studies demonstrating an association of specific types with leukemia. KIRs and their corresponding HLA class 1 ligands were investigated in Saudi patients with ALL and AML and compared to healthy controls. The homozygous A haplotype was found significantly more often in ALL patients ≤18 years-old than in control individuals. No significant association was observed in KIRs and their corresponding HLA ligands in this study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 78, Issues 7–8, July–August 2017, Pages 510-514
نویسندگان
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