|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5666661||1407826||2017||3 صفحه PDF||سفارش دهید||دانلود کنید|
- Plasma cells can be short-lived plasmablast or long-lived memory plasma cells.
- Memory plasma cells provide persisting antibody titers for years, even decades.
- Protective memory plasma cells are important for longlasting immunity to infections.
- Pathogenic autoreactive memory plasma cells exist in autoimmunity.
- They are refractory to conventional immunosuppression and their depletion constitutes a therapeutic challenge.
The immune system can be divided into two major parts: innate and adaptive immunity. Adaptive immunity is characterized by its major cellular players: the B and T cells. B cells will, in the context of an immune reaction, differentiate into plasma cells. These plasma cells produce antibodies, which are secreted. Antibodies are characterized by their specificity against a selected antigen and by their isotype. The isotype changes with the duration or phase of the immune reaction. Early immune reactions are usually characterized by the predominant production of IgM antibodies. With the persistence of the immune reaction immunoglobulin class switch occurs and plasma cells will produce IgG, IgE or IgA-antibodies (Radbruch et al., 2006) .
Journal: Immunology Letters - Volume 189, September 2017, Pages 10-12