کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5666794 | 1591737 | 2017 | 4 صفحه PDF | دانلود رایگان |
- Ivacaftor exhibits concentration-dependent bactericidal activity against S. aureus.
- Ivacaftor has potent in vivo activity comparable to vancomycin in a murine neutropenic thigh infection model.
- Ivacaftor could potentially be repurposed against S. aureus infections
Drug repurposing of non-antimicrobials is a novel method to augment a seriously depleted drug pipeline for targeting drug-resistant pathogens. This article highlights the potent antimicrobial activity of Ivacaftor against Staphylococcus aureus, including vancomycin- and other multidrug-resistant strains. The potent activity of Ivacaftor in vivo is also demonstrated in a murine neutropenic thigh infection model. Taken together, these results support the potential of Ivacaftor as an antimicrobial agent for the treatment of staphylococcal infections.
Journal: International Journal of Antimicrobial Agents - Volume 50, Issue 3, September 2017, Pages 389-392