|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5666920||1591742||2017||3 صفحه PDF||سفارش دهید||دانلود کنید|
- Over 30% of Pseudomonas aeruginosa isolated in 8 Korean hospitals were carbapenem-resistant.
- All metallo-Î²-lactamase-producing isolates belonged to ST235, a worldwide high-risk clone.
- Of 33 IMP-6-producing ST235 isolates, 9 were colistin-resistant and exhibited resistance to all antimicrobials tested.
In this study, the prevalence and characteristics of metallo-Î²-lactamase (MBL)-producing Pseudomonas aeruginosa isolates in South Korea were investigated. Among 215 P. aeruginosa isolates collected from eight hospitals, 77 (35.8%) and 72 (33.5%) were resistant to imipenem and meropenem, respectively. Of the 77 imipenem-resistant isolates, MBL genes were identified in 34 isolates (blaIMP-6 in 33 isolates and blaVIM-2 in 1 isolate). All of the MBL-producing isolates belonged to a globally prevailing genotype, sequence type 235 (ST235), and all of the IMP-6-producing isolates showed a deletion of nucleotide 209 of the porin gene oprD. Of the 33 IMP-6-producing ST235 isolates, 9 were resistant to colistin and exhibited resistance to all antimicrobial agents included in this study. PhoPQ and PmrAB amino acid alterations were not identical in the colistin-resistant isolates, indicating independent emergence of colistin resistance in this high-risk clone. Carbapenem resistance in P. aeruginosa has increased in South Korea owing to the dissemination of IMP-6-producing ST235 isolates, which showed high-level resistance to meropenem. Emergence of colistin resistance in the disseminated resistant clone would be a significant threat because few alternatives are left for the treatment of systemic infections.
Journal: International Journal of Antimicrobial Agents - Volume 49, Issue 6, June 2017, Pages 767-769