کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5666920 1407838 2017 3 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Emergence of colistin resistance in Pseudomonas aeruginosa ST235 clone in South Korea
کلمات کلیدی
Metallo-β-lactamase; MBL; IMP-6; ST235; Colistin resistance;
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Emergence of colistin resistance in Pseudomonas aeruginosa ST235 clone in South Korea
چکیده انگلیسی

•Over 30% of Pseudomonas aeruginosa isolated in 8 Korean hospitals were carbapenem-resistant.•All metallo-β-lactamase-producing isolates belonged to ST235, a worldwide high-risk clone.•Of 33 IMP-6-producing ST235 isolates, 9 were colistin-resistant and exhibited resistance to all antimicrobials tested.

In this study, the prevalence and characteristics of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa isolates in South Korea were investigated. Among 215 P. aeruginosa isolates collected from eight hospitals, 77 (35.8%) and 72 (33.5%) were resistant to imipenem and meropenem, respectively. Of the 77 imipenem-resistant isolates, MBL genes were identified in 34 isolates (blaIMP-6 in 33 isolates and blaVIM-2 in 1 isolate). All of the MBL-producing isolates belonged to a globally prevailing genotype, sequence type 235 (ST235), and all of the IMP-6-producing isolates showed a deletion of nucleotide 209 of the porin gene oprD. Of the 33 IMP-6-producing ST235 isolates, 9 were resistant to colistin and exhibited resistance to all antimicrobial agents included in this study. PhoPQ and PmrAB amino acid alterations were not identical in the colistin-resistant isolates, indicating independent emergence of colistin resistance in this high-risk clone. Carbapenem resistance in P. aeruginosa has increased in South Korea owing to the dissemination of IMP-6-producing ST235 isolates, which showed high-level resistance to meropenem. Emergence of colistin resistance in the disseminated resistant clone would be a significant threat because few alternatives are left for the treatment of systemic infections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 49, Issue 6, June 2017, Pages 767-769
نویسندگان
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