کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5667038 | 1591743 | 2017 | 4 صفحه PDF | دانلود رایگان |
- Synthesis and antimicrobial activity of cyclam derivatives are described.
- Cyclam [H2{H2(4-CF3PhCH2)2Cyclam}](CH3COO)2â
(CH3COOH)2 has bactericidal and fungicidal activities.
- Cyclam derivatives represent a potential new class of antibiotics.
The antimicrobial activity and toxicity to nematodes of the cyclam salt [H2{H2(4-CF3PhCH2)2Cyclam}](CH3COO)2â (CH3COOH)2 were evaluated. Estimated minimum inhibitory concentrations (MICs) of 9, 261 and 15âµg/mL were obtained for Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, respectively. For selected Candida spp., the estimated MICs obtained ranged from 32âµg/mL to 63âµg/mL. Bactericidal activity was demonstrated but the compound was not reliably fungicidal. Concentrations of the cyclam salt up to 32âµg/mL did not significantly affect survival of the nematode Caenorhabditis elegans; however, concentrations equal or above this value significantly affected nematode survival in a dose-dependent manner.
Journal: International Journal of Antimicrobial Agents - Volume 49, Issue 5, May 2017, Pages 646-649