کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5667937 1592273 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis
چکیده انگلیسی


- Dendritic cells are potential therapeutic targets in autoimmune neuroinflammation.
- Studied with transgenic mice and experimental autoimmune encephalomyelitis (EAE).
- Conditional ablation of DCs during disease initiation leads to exacerbated EAE course.
- No increase in regulatory T cells (Treg) in secondary lymphoid organs and CNS.
- Evidence for a protective role of DCs in the initiating phase of EAE.

Counter-balancing regulatory mechanisms, such as the induction of regulatory T cells (Treg), limit the effects of autoimmune attack in neuroinflammation. However, the role of dendritic cells (DCs) as the most powerful antigen-presenting cells, which are intriguing therapeutic targets in this context, is not fully understood. Here, we demonstrate that conditional ablation of DCs during the priming phase of myelin-specific T cells in experimental autoimmune encephalomyelitis (EAE) selectively aborts inducible Treg (iTreg) induction, whereas generation of T helper (Th)1/17 cells is unaltered. DCs facilitate iTreg induction by creating a milieu with high levels of interleukin (IL)-2 due to a strong proliferative response. In the absence of DCs, B220+ B cells take over priming of Th17 cells in the place of antigen-presenting cells (APCs), but not the induction of iTreg, thus leading to unregulated, severe autoimmunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 76, January 2017, Pages 108-114
نویسندگان
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