کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5670771 1592750 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Trypanosoma cruzi modulates gene expression of plasma membrane repair-related proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Trypanosoma cruzi modulates gene expression of plasma membrane repair-related proteins
چکیده انگلیسی


- Trypanosoma cruzi modulates expression of plasma membrane repair-related genes.
- The number of host cell interacting parasites correlates to fold change.
- Rapamycin treatment impaired T. cruzi driven gene expression.

Plasma membrane injury and repair is particularly prevalent in muscle cells. Here, we aimed to verify dysferlin, acid sphingomyelinase and transcriptional factor EB gene expression during Trypanosoma cruzi infection in vitro and in vivo. Our results showed that the parasite modulates gene expression of these proteins in a way dependent on the number of plasma membrane interacting parasites and in a rapamycin-sensitive manner.

102

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Tropica - Volume 174, October 2017, Pages 153-157
نویسندگان
, , , , , , ,