کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5670948 1592757 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Myocarditis in different experimental models infected by Trypanosoma cruzi is correlated with the production of IgG1 isotype
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Myocarditis in different experimental models infected by Trypanosoma cruzi is correlated with the production of IgG1 isotype
چکیده انگلیسی


- High IgG1 showed a significant correlation with myocarditis in both experimental models.
- IgG1 could be a good marker to demonstrate myocarditis intensity in Chagas disease.
- Different parasite strains are able to induce similar infectivity in different hosts.
- Different experimental models may respond differently to Trypanosoma cruzi.

This study was designed to verify the relationship between IgG antibodies isotypes and myocarditis in Trypanosoma cruzi infection using mice and dogs infected with different T. cruzi strains. The animals were infected with benznidazole-susceptible Berenice-78 and benznidazole-resistant AAS and VL-10 strains. The IgG subtypes were measured in serum samples from dogs (IgG, IgG1, and IgG2) and mice (IgG, IgG1, IgG2a, and IgG2b). The infection of dogs with VL-10 strain induced the highest levels of heart inflammation while intermediate and lower levels were detected with Berenice-78 and AAS strains, respectively. Similar results were found in mice infected with VL-10, but not in those infected with AAS or Berenice-78 strains. The AAS strain induced higher levels of heart inflammation in mice, while Berenice-78 strain was not able to induce it. Correlation analysis between myocarditis and antibody reactivity index revealed very interesting results, mainly for IgG and IgG1, the latter being the most exciting. High IgG1 showed a significant correlation with myocarditis in both experimental models, being more significant in dogs (r = 0.94, p < 0.0001) than in mice (r = 0.58, p = 0.047). Overall, our data suggest that IgG1 could be a good marker to demonstrate myocarditis intensity in Chagas disease.

IgG1 could be a good marker to demonstrate myocarditis intensity in Chagas disease using mice and dogs infected with different T. cruzi straints.116

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Tropica - Volume 167, March 2017, Pages 40-49
نویسندگان
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