کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5685368 | 1598225 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Kidney Transplantation for Kidney Failure Due to Multiple Myeloma: Case Reports
ترجمه فارسی عنوان
پیوند کلیه برای نارسایی کلیه به علت چندگانه میلوما: گزارش موارد
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کلمات کلیدی
RRT modalityRemission - انتقادHematologic malignancy - بدخیمی هماتولوژیکBortezomib - بورتِـزومیبend-stage renal disease (ESRD) - بیماری کلیوی مرحله پایانی (ESRD)renal replacement therapy (RRT) - درمان جایگزینی کلیه (RRT)Outcomes - عواقبMultiple myeloma - مولتیپل میلوماKidney failure - نارسایی کلیهKidney transplantation - پیوند کلیهCase report - گزارش موردی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
Transplantation centers have historically considered a history of multiple myeloma as a contraindication to kidney transplantation due to high recurrence rates and poor transplant survival. However, there have been significant advances in the treatment of multiple myeloma, with improved patient survival, which may allow for successful kidney transplantation in these patients. We report on 4 patients who underwent kidney transplantation at our institution between 2009 and 2015 after having achieved a very good partial response or better with chemotherapy and autologous stem cell transplantation. All 4 patients received kidneys from living donors; 2 underwent induction therapy with basiliximab, and 2, with thymoglobulin. One patient had progression of myeloma, which responded well to therapy. All had functioning transplants at 1 year after kidney transplantation. No patients experienced a rejection episode or infections with BK polyomavirus or cytomegalovirus, with follow-up ranging from 16 to 58 months after kidney transplantation. Our experience suggests that kidney transplantation is feasible in a subset of patients with multiple myeloma. Future studies are necessary to compare outcomes in these patients with other high-risk patients undergoing kidney transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 69, Issue 6, June 2017, Pages 858-862
Journal: American Journal of Kidney Diseases - Volume 69, Issue 6, June 2017, Pages 858-862
نویسندگان
Thuy X. MD, Jeffrey L. MD, Carmen A. MD, Allison B. MD,