کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5716548 1606691 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between matrix metaloproteinases 2-1306C/T polymorphism and the risk of coronary artery disease in Iranian population
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Association between matrix metaloproteinases 2-1306C/T polymorphism and the risk of coronary artery disease in Iranian population
چکیده انگلیسی


- We want to uncover the landscope of genetic variation associated with coronary artery disease in Iranian patients.
- We investigate possible association between MMP2 gene and risk of coronary artery disease.
- We want to find a panel of SNPs from different genes which can influence on the risk of coronary artery disease in our patients.
- Finding clinical role of genetic variations on coronary artery disease characteristics.

BackgroundCoronary Artery Disease (CAD) represents the most important cause of sudden cardiac death. Interaction between genetic and environmental factors, individual susceptibility of the development of CAD is one of the MMP2 genes. Genetic variants' dysfunction of the MMP2 gene associated with the risk of CAD. The aim of the present study is to assess possible association between risk of Coronary Artery Disease and MMP2-1306C/T polymorphism.MethodsThis case-control study contains a total number of 344 subjects, including 215 patients with CAD and 129 of controls. Genomic DNA was isolated from whole blood and genotyping was performed by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR- RFLP) method.ResultsThis study reveals the result that about 3.5% of CAD patients had TT genotype while 30.4% of them had CT genotype. Corresponding figures for subjects without CAD were zero and 52.6% respectively. These differences were statistically significant (P = 0.002). Frequencies of T allele among patients with and without CAD were 18.71% and 26.28% respectively (p = 0.04). The odds ratio between T allele and CAD was 0.64 (p = 0.055). we couldn't trace significant differences among alleles in Gensini score, Gesnsini score's median among patients carried out TT, CT and CC genotypes were 4, 2 and 2 respectively (p = 0.3).ConclusionsResult of this study provides some evidences that the MMP2-1306 polymorphism can be associated with coronary artery disease. Further longitudinal studies including more sample sizes are required to confirm this protective effect.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathophysiology - Volume 24, Issue 3, September 2017, Pages 185-189
نویسندگان
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