کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5719186 | 1607418 | 2017 | 6 صفحه PDF | دانلود رایگان |
ObjectiveTo assess associations between breastfeeding and iron status at 9 months of age in 2 samples of Chinese infants.Study designAssociations between feeding at 9 months of age (breastfed as sole milk source, mixed fed, or formula fed) and iron deficiency anemia (IDA), iron deficiency, and iron sufficiency were determined in infants from Zhejiang (n = 142) and Hebei (nâ=â813) provinces. Iron deficiency was defined as body ironâ<â0âmg/kg, and IDA as iron deficiencyâ+âhemoglobinâ<â110âg/L. Multiple logistic regression assessed associations between feeding pattern and iron status.ResultsBreastfeeding was associated with iron status (Pâ<â.001). In Zhejiang, 27.5% of breastfed infants had IDA compared with 0% of formula-fed infants. The odds of iron deficiency/IDA were increased in breastfed and mixed-fed infants compared with formula-fed infants: breastfed vs formula-fed OR, 28.8 (95% CI, 3.7-226.4) and mixed-fed vs formula-fed OR, 11.0 (95% CI, 1.2-103.2). In Hebei, 44.0% of breastfed infants had IDA compared with 2.8% of formula-fed infants. With covariable adjustment, odds of IDA were increased in breastfed and mixed-fed groups: breastfed vs formula-fed OR, 78.8 (95% CI, 27.2-228.1) and mixed-fed vs formula-fed OR, 21.0 (95% CI, 7.3-60.9).ConclusionsIn both cohorts, the odds of iron deficiency/IDA at 9 months of age were increased in breastfed and mixed-fed infants, and iron deficiency/IDA was common. Although the benefits of breastfeeding are indisputable, these findings add to the evidence that breastfeeding in later infancy identifies infants at risk for iron deficiency/IDA in many settings. Protocols for detecting and preventing iron deficiency/IDA in breastfed infants are needed.Trial registrationClinicalTrials.gov: NCT00642863 and NCT00613717.
Journal: The Journal of Pediatrics - Volume 181, February 2017, Pages 56-61