کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5719391 | 1607415 | 2017 | 5 صفحه PDF | دانلود رایگان |
ObjectiveTo determine if the reflux finding score (RFS), a validated score for airway inflammation, correlates with gastroesophageal reflux measured by multichannel intraluminal impedance (MII) testing, endoscopy, and quality of life scores.Study designWe performed a prospective, cross-sectional cohort study of 77 children with chronic cough undergoing direct laryngoscopy and bronchoscopy, esophagogastroduodenoscopy, and MII testing with pH (pH-MII) between 2006 and 2011. Airway examinations were videotaped and reviewed by 3 blinded otolaryngologists each of whom assigned RFS to the airways. RFS were compared with the results of reflux testing (endoscopy, MII, symptom scores). An intraclass correlation coefficient was calculated for the degree of agreement between otolaryngologists' RFS. Receiver operating characteristic curves were created to determine the sensitivity of the RFS. Spearman correlation was calculated between the RFS and reflux measurements by pH-MII.ResultsThe meanâ±âSD RFS was 12â±â4. There was no correlation between pH-MII variables and mean RFS (|r|â<â0.15). The concordance correlation coefficient for RFS between otolaryngologists was low (intraclass correlation coefficientâ=â0.32). Using pH-metry as a gold standard, the positive predictive value for the RFS was 29%. Using MII as the gold standard, the positive predictive value for the RFS was 40%. There was no difference in the mean RFS in patients with (12â±â4) and without (12â±â3) esophagitis (Pâ=â.9). There was no correlation between RFS and quality of life scores (|r|â<â0.15, Pâ>â.3).ConclusionsThe RFS cannot predict pathologic gastroesophageal reflux and an airway examination should not be used as a basis for prescribing gastroesophageal reflux therapies.
Journal: The Journal of Pediatrics - Volume 183, April 2017, Pages 127-131