کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5721350 1608045 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleVolumetric and morphological characteristics of the hippocampus are associated with progression to schizophrenia in patients with first-episode psychosis
ترجمه فارسی عنوان
اصل مقاله اندازه و ویژگی های مورفولوژیکی هیپوکامپ همراه با پیشرفت اسکیزوفرنی در بیماران مبتلا به روانپریشی اول
کلمات کلیدی
قسمت اول روانپریشی، هیپوکامپ، تجزیه و تحلیل شکل، جنون جوانی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی

BackgroundAbnormalities in the hippocampus have been implicated in the pathophysiology of psychosis. However, it is still unclear whether certain abnormalities are a pre-existing vulnerability factor, a sign of disease progression or a consequence of environmental factors. We hypothesized that first-episode psychosis patients who progress to schizophrenia after one year of follow up will display greater volumetric and morphological changes from the very beginning of the disorder.MethodsWe studied the hippocampus of 41 patients with a first-episode psychosis and 41 matched healthy controls. MRI was performed at the time of the inclusion in the study. After one year, the whole sample was reevaluated and divided in two groups depending on the diagnoses (schizophrenia vs. non-schizophrenia).ResultsPatients who progressed to schizophrenia showed a significantly smaller left hippocampus volume than control group and no-schizophrenia group (F = 3.54; df = 2, 77; P = 0.03). We also found significant differences in the morphology of the anterior hippocampus (CA1) of patients with first-episode psychosis who developed schizophrenia compared with patients who did not.ConclusionsThese results are consistent with the assumption of hyperfunctioning dopaminergic cortico-subcortical circuits in schizophrenia, which might be related with an alteration of subcortical structures, such as the hippocampus, along the course of the disease. According with these results, hippocampus abnormalities may serve as a prognostic marker of clinical outcome in patients with a first-episode psychosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Psychiatry - Volume 45, September 2017, Pages 1-5
نویسندگان
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