Etiologic specificity of waking Cortisol: Links with maternal history of depression and anxiety in adolescent girls

- Offspring at risk for anxiety disorders had higher cortisol 30 min post waking.
- Offspring at risk for anxiety disorders had higher cortisol throughout the day.
- The anxiety effect was primarily driven by maternal history of panic/agoraphobia.
- Offspring of mothers with more anxiety diagnoses had the highest cortisol.
- Maternal depression history was not associated with offspring cortisol.

BackgroundMany previous studies have indicated that individuals who are depressed or at risk for depression are characterized by increased levels of morning cortisol and a greater cortisol awakening response (CAR). However, despite the high comorbidity between depressive and anxiety disorders, fewer studies have examined whether these diurnal cortisol abnormalities are also characteristic of anxiety or risk for anxiety.MethodsIn the present study we examined cortisol in a community sample of 476 female adolescents and related it to maternal history of depression and/or anxiety disorders. Salivary cortisol was collected at waking, 30 min post waking, and in the evening on three weekdays.ResultsContrary to prior results, offspring at risk for depression did not have increased morning cortisol or CAR. However, offspring at risk for anxiety disorders had elevated 30 min cortisol and total cortisol produced throughout the day; this effect was primarily driven by offspring of mothers with panic disorder or agoraphobia. Additionally, levels of cortisol were highest among offspring of mothers with multiple anxiety diagnoses.LimitationsThe study is limited to female adolescents and maternal diagnostic history. Additionally, some diagnoses could not be examined as a result of too few cases (e.g. GAD).ConclusionsOverall, these results underscore the importance of considering anxiety when examining the association of diurnal cortisol abnormalities with risk for psychopathology, as it may have influenced prior observations of elevated morning cortisol in depression.