کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5731828 | 1611929 | 2017 | 9 صفحه PDF | دانلود رایگان |
- PM-HCC patients might acquire superior prognosis when intrahepatic tumors were controlled by LR.
- PMT might provide potential survival benefits in well selected PM-HCC patients.
- Synchronous PM-HCC, AFPâ¥400 ng/ml, no IHT after LR, IHRM when PM repeated were inferior independent prognostic factors.
- Well designed, multi-institutional studies with larger patient number were needed.
BackgroundTo explore the therapeutic significance and indications of pulmonary metastasectomy (PMT) in hepatocellular carcinoma (HCC) patients with pulmonary metastasis (PM) following liver resection (LR).Patients and methodsPM-HCC patients who underwent LR were retrospectively enrolled, and survival outcomes and prognostic factors were analyzed. Patients were divided into PMT and non-PMT group, and propensity score matching (PSM) analysis was used for survival comparison. Prognostic analysis and survival comparisons were performed specifically in PMT patients.ResultsNinety-seven patients were enrolled, among which twenty-six underwent PMT while seventy-one did not. Survival outcome was superior in PMT group compared to non-PMT group (33.5 vs. 10.5 months) (p = 0.003), while no statistical difference was found after PSM analysis (33.5 vs. 11.2 months) (p = 0.138). Synchronous PM-HCC, serum alpha fetal proteinâ¥400 ng/ml at PM diagnosis, no intrahepatic treatments (LR, ablation or transarterial chemoembolization) after LR, intrahepatic recurrence or metastasis at repeated PM diagnosis were inferior independent prognostic factors in PMT patients (p < 0.05). Superior survival outcomes were seen in candidate PMT patients when corresponding indications were satisfied (p = 0.014, p = 0.005).ConclusionPMT might provide potential survival benefits in well selected PM-HCC patients who underwent LR. Well designed, multi-institutional studies with larger patient number were still to be required.
Journal: International Journal of Surgery - Volume 48, December 2017, Pages 23-31