کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5735693 | 1612913 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bicuculline, a GABAA-receptor antagonist, blocked HPA axis activation induced by ghrelin under an acute stress
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کلمات کلیدی
5-HTACTHIntermediate medial mesopalliumGHS-RIPSPmIPSCsAVPCRHBICOpen field test - آزمایش میدان بازimm - انحصارminiature inhibitory postsynaptic currents - جریان ممانعت کننده پسینپتیکAnxiety-like behavior - رفتار اضطراب مانندSerotonin - سروتونینPVN - مالیات بر ارزش افزودهbicuculline methiodide - متیکویدید bicucullineHPA axis - محور هیپوتالاموس-هیپوفیز-آدرنالhypothalamic–pituitary–adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالparaventricular nucleus - هسته پروژسترویکadrenocorticotropic hormone - هورمون adrenocorticotropiccorticotropin-releasing hormone - هورمون آزاد کننده کورتیکوتروپینinhibitory post-synaptic potentials - پتانسیل های پسا سیناپسی مهارکنندهCorticosterone - کورتیکوسترونGABAAR - گابارGhrelin - گرلینGABAA receptor - گیرنده GABAA یا گیرنده گاباgrowth hormone secretagogue receptor - گیرنده ترشح هورمون رشد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ghrelin is a peptide of 28 amino acids with a homology between species, which acts on the central nervous system to regulate different actions, including the control of growth hormone secretion and metabolic regulation. It has been suggested that central ghrelin is a mediator of behavior linked to stress responses and induces anxiety in rodents and birds. Previously, we observed that the anxiogenic-like behavior induced by ghrelin injected into the intermediate medial mesopallium (IMM) of the forebrain was blocked by bicuculline (a GABAA receptor competitive antagonist) but not by diazepam (a GABAA receptor allosteric agonist) in neonatal meat-type chicks (Cobb). Numerous studies have indicated that hypothalamic-pituitary-adrenal (HPA) axis activation mediates the response to stress in mammals and birds. However, it is still unclear whether this effect of ghrelin is associated with HPA activation. Therefore, we investigated whether anxiety behavior induced by intra-IMM ghrelin and mediated through GABAA receptors could be associated with HPA axis activation in the neonatal chick. In the present study, in an Open Field test, intraperitoneal bicuculline methiodide blocked anxiogenic-like behavior as well as the increase in plasma ACTH and corticosterone levels induced by ghrelin (30Â pmol) in neonatal chicks. Moreover, we showed for the first time that a competitive antagonist of GABAA receptor suppressed the HPA axis activation induced by an anxiogenic dose of ghrelin. These results show that the anxiogenic ghrelin action involves the activation of the HPA axis, with a complex functional interaction with the GABAA receptor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 320, 1 March 2017, Pages 464-472
Journal: Behavioural Brain Research - Volume 320, 1 March 2017, Pages 464-472
نویسندگان
M.S. Gastón, M.P. Cid, N.A. Salvatierra,