کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5736340 1613228 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Purkinje cell as a model of synaptogenesis and synaptic specificity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
The Purkinje cell as a model of synaptogenesis and synaptic specificity
چکیده انگلیسی
Since the groundbreaking work of Ramon y Cajal, the cerebellar Purkinje cell has always represented an ideal model for studying the organization, development and function of synaptic circuits. Purkinje cells receive distinct types of glutamatergic and GABAergic synapses, each characterized by exquisite sub-cellular and molecular specificity. The formation and refinement of these connections results from a temporally-regulated sequence of events that involves molecular interactions between distinct sets of secreted and surface proteins, as well as activity-dependent competition between converging inputs. Insights into the mechanisms controlling synaptic specificity in Purkinje cells may help understand synapse development also in other brain regions and disclose circuit abnormalities that underlie neurodevelopmental disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 129, March 2017, Pages 12-17
نویسندگان
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