کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737746 | 1614732 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dual influences of early-life maternal deprivation on histone deacetylase activity and recognition memory in rats
ترجمه فارسی عنوان
تأثیر دوگانه محرومیت مادران زودرس بر فعالیت هیستون دیاسکتیلاز و حافظه شناختی در موش صحرایی
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کلمات کلیدی
HDACLTMPost-natal stressBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Histone acetylation - استیلیت هیستونanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceObject recognition - تشخیص شیlong-term memory - حافظه بلندمدتSodium butyrate - سدیم butyrateBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزhistone deacetylase - هیستون داستیلاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Exposure to stress early in life may negatively impact nervous system functioning, including increasing the proneness to learning and memory impairments later in life. Maternal deprivation, a model of early-life stress, hinders memory in adult rats and lessens brain-derived neurotrophic factor (BDNF) levels in the hippocampus in a very heterogeneous way among individuals. The main goal of the present study was to investigate the possible epigenetic modulation underlying recognition memory impairment and reduced BDNF levels in the hippocampus of adult maternally deprived rats. We also evaluated the potential ameliorating properties of the histone deacetylase (HDAC) inhibitor, sodium butyrate, on memory deficits and BDNF changes related to maternal deprivation. Maternally deprived animals were categorized as 'inferior learners' and 'superior learners' according to their performance in object recognition memory task in comparison to controls. Results indicated that HDAC activity was higher in individuals submitted to maternal deprivation with the worst cognitive performance (inferior learners). Acute administration of sodium butyrate increased histone H3 acetylation and BDNF levels, and restored recognition memory in maternally deprived animals with the worst cognitive performance. Moreover, we also showed that there is a positive correlation between BDNF levels and memory performance. Taken together, the results indicated that HDAC inhibitors could be considered as a possible therapeutic agent to improve cognitive performance in inferior learners. Further studies need to be conducted for a better comprehension of the mechanisms related to persistent alterations observed in adult life induced by early stressful circumstances and those leading to resilience.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 360-370
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 360-370
نویسندگان
Manoel Osório Albuquerque Filho, Betânia Souza de Freitas, Rebeca Carvalho Lacerda Garcia, Pedro Castilhos de Freitas Crivelaro, Nadja Schröder, Maria Noêmia Martins de Lima,