کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738328 1615044 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research articleRoyal jelly decreases corticosterone levels and improves the brain antioxidant system in restraint and cold stressed rats
ترجمه فارسی عنوان
مقاله پژوهشی ژله سرخ شده سطح کورتیکواسترون را کاهش می دهد و سیستم آنتی اکسیدانی مغز را در موش های مقاوم و سرماخوردگی سرد بهبود می بخشد
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Restraint and cold stress increases the plasmatic corticosterone levels.
- Restraint and cold stress worsens the antioxidant defense system in the brain tissues.
- Royal jelly decreases plasmatic corticosterone levels.
- Royal jelly improves the antioxidant defense system in the brain tissues.

Restraint and cold stress induces the hypothalamic-pituitary-adrenal (HPA) axis to release corticosterone from the adrenal gland, which can worsen the antioxidant defense system in the central nervous system. Here, we investigated the corticosterone levels and the antioxidant defense system in the cerebellum and brain, as well as in its isolated regions, such as cerebral cortex, striatum and hippocampus of stressed rats supplemented with royal jelly (RJ). Wistar rats were supplemented with RJ for 14 days and the stress induction started on the 7th day. Stressed rats increased corticosterone levels, glycemia and lipid peroxidation in the brain and cerebellum, cerebral cortex and hippocampus besides reduced glutathione defense system in the brain and striatum. Rats supplemented with RJ decreased corticosterone, maintained glycemia and decreased lipid peroxidation in the brain, cerebellum, as well as striatum and hippocampus, besides improved glutathione defense system in cerebral cortex and striatum. This study suggests an anti-stress and neuroprotective effect of RJ under stress conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 655, 10 August 2017, Pages 179-185
نویسندگان
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