کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738629 1615045 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research articleIntrinsic functional connectivity alteration of dorsal and rostral anterior cingulate cortex in obsessive-compulsive disorder: A resting fMRI study
ترجمه فارسی عنوان
تحقیقاتی تغییرات ارتباطی عملیاتی درونی مفصل گردن و مفصل گردن رحم در اختلال وسواسی- اجباری: یک مطالعه فماریسم استراحت
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- OCD showed decreased functional connectivity between rACC and DLPFC.
- OCD displayed increased functional connectivity between dACC and caudate.
- Functional connectivity of dACC-caudate in OCD was positively correlated with clinical scores.

Cortico-striato-thalamo-cortical (CSTC) circuit has been implicated in OCD pathophysiology by converging neuroimaging findings. The anterior cingulate cortex (ACC), as an important part within CSTC circuit, plays a critical role in OCD etiology. The ACC can be divided into dorsal and rostral parts anatomically, which are involved in cognitive process and emotional function, respectively. However, the diverse function of intrinsic signals from dorsal and rostral ACC regions remains unclear in OCD study. In this work, we applied resting-state functional magnetic resonance imaging (rs-fMRI) technology to investigate and differentiate the functional connectivity (FC) characteristics between dACC and rACC in unmedicated OCD patients. Also, the correlation between the altered FC and clinical symptom severity was analyzed. Decreased FC of rACC-DLPFC and increased FC between dACC and caudate were found. Moreover, the altered dACC-caudate FC was positively correlated with total Y-BOCS and compulsion score in OCD patients. Our findings implied the crossed function of dorsal and rostral circuits in the pathophysiologic mechanism of OCD. The dorsal cingulate-striatum functional pathway served as a potential biomarker for OCD symptomatology and merits further investigations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 654, 27 July 2017, Pages 86-92
نویسندگان
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