کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5739073 1615358 2017 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The therapeutic potential of cell identity reprogramming for the treatment of aging-related neurodegenerative disorders
ترجمه فارسی عنوان
پتانسیل درمانی از برنامه ریزی هویت سلولی برای درمان اختلالات نورولوژیک ناشی از پیری
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Neural cell identity reprogramming strategies aim to treat age-related neurodegenerative disorders with newly induced neurons that regenerate neural architecture and functional circuits in vivo. The isolation and neural differentiation of pluripotent embryonic stem cells provided the first in vitro models of human neurodegenerative disease. Investigation into the molecular mechanisms underlying stem cell pluripotency revealed that somatic cells could be reprogrammed to induced pluripotent stem cells (iPSCs) and these cells could be used to model Alzheimer disease, amyotrophic lateral sclerosis, Huntington disease, and Parkinson disease. Additional neural precursor and direct transdifferentiation strategies further enabled the induction of diverse neural linages and neuron subtypes both in vitro and in vivo. In this review, we highlight neural induction strategies that utilize stem cells, iPSCs, and lineage reprogramming to model or treat age-related neurodegenerative diseases, as well as, the clinical challenges related to neural transplantation and in vivo reprogramming strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 157, October 2017, Pages 212-229
نویسندگان
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