کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5746151 | 1618791 | 2017 | 8 صفحه PDF | دانلود رایگان |
- Tebuconazole reduced exploratory behavior in larvae.
- Tebuconazole showed decreased distance travelled in adults.
- Tebuconazole inhibited AChE activity in larvae and in zebrafish adult brain.
- Tebuconazole increased AChE gene expression in larvae, but not in zebrafish adults.
In this study, we evaluated the effects of tebuconazole on morphology and exploratory larvae behavior and adult locomotion. Furthermore, we analyzed the effects of this fungicide on AChE activity and gene expression in zebrafish larvae and in the adult zebrafish brain. Tebuconazole (4Â mg/L) increased the ocular distance in larvae and reduced the distance travelled, absolute turn angle, line crossing and time outside area in exposed larvae. Moreover, adult zebrafish that were exposed to this fungicide (4 and 6Â mg/L) showed a decrease in distance travelled and mean speed when compared to the control group. However, tebuconazole did not alter the number of line crossings or time spent in the upper zone. Tebuconazole inhibited AChE activity at concentrations of 4Â mg/L for larvae and 4 and 6Â mg/L in the adult zebrafish brain. However, this fungicide did not alter AChE gene expression in the adult zebrafish brain but increased AChE mRNA transcript levels in larvae. These findings demonstrated that tebuconazole could modulate the cholinergic system by altering AChE activity and that this change may be associated with the reduced locomotion of these animals.
Journal: Chemosphere - Volume 180, August 2017, Pages 483-490