کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5746227 1618787 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The relationship between the length of surface ligand and effects of CdTe quantum dots on the physiological functions of isolated mitochondria
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
The relationship between the length of surface ligand and effects of CdTe quantum dots on the physiological functions of isolated mitochondria
چکیده انگلیسی


- MPA-CdTe QDs had a stronger effect on MPT than TGA-CdTe QDs.
- The weaker effect of TGA-CdTe QDs on MPT might be owing to their better stability and thus less amount of released Cd2+.
- Surface ligands play an important role in the toxicity of CdTe quantum dots at the sub-cellular level.

The potential toxicity of Quantum dots (QDs) should be assessed comprehensively for their fast spreading applications. Many studies have shown the toxicity of QDs is associated with their surface ligands. In this work, two analog ligands with one carbon difference, 2-mercaptoacetic acid (TGA) and 3-mercaptopropionic acid (MPA) were used as coating materials in the syntheses of two types of CdTe QDs with similar physicochemical properties. Then the biological effects of QDs on isolated mitochondria were studied. It was found that the two types of QDs could impair mitochondrial respiration and induce mitochondrial permeability transition (MPT). However, as compared with TGA-CdTe QDs, MPA-CdTe QDs had a stronger effect on MPT. The weaker effect of TGA-CdTe QDs on MPT might be owing to their better stability and thus less amount of released Cd2+, which could be further explained by the stronger affinity between the ligand (TGA) and the cadmium complexes in the crystal growth of QDs. These results highlighted the importance of ligands responsible for the toxicity of QDs at the sub-cellular level.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 184, October 2017, Pages 1108-1116
نویسندگان
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