کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5749492 1619152 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blood cell responses and metallothionein in the liver, kidney and muscles of bullfrog tadpoles, Lithobates catesbeianus, following exposure to different metals
ترجمه فارسی عنوان
پاسخ های سلولی خون و فلوتونیئین در کبد، کلیه و عضلات دلفریب تولپا، لیتوباتس کایتس بیوانس، تحت قرار گرفتن در معرض فلزات مختلف
کلمات کلیدی
فلز روی، فلز مس، کادمیوم، بافت اریتروسیت ها، لکوسیت ها،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


- Metal accumulation occurred in all tissues.
- Metallothionein levels in tissues were higher after the exposure to the combined metals.
- Zinc, copper and cadmium either alone or combined affect blood parameters.

The hematological parameters and metallothionein (MT) levels in the liver, kidney and muscles were measured in bullfrog tadpoles, Lithobates catesbeianus, following exposures to 1 μg L−1 of zinc (Zn), copper (Cu) and cadmium (Cd) alone or in combination (1:1 and 1:1:1) for 2 and 16 days. Metal accumulation occurred in all organs, with the highest values found in the kidney, followed by the muscles and liver. After exposure to isolated metals, the accumulation was in the following order: Cd > Zn > Cu in the liver and muscles and Cd > Cu > Zn in the kidney. Exposure to combined metals (Zn + Cu, Zn + Cd, Cu + Cd and Zn + Cu + Cd) revealed complex responses, such as metal accumulation increased or decreased over the exposure periods, suggesting possible competion at the uptake sites and/or metabolization and elimination processes in each organ. The MT concentration increased in the organs of tadpoles following metal exposure alone, mainly in the liver, for both periods. After the combined exposures, the MT levels were higher in the liver and muscles at 16 days, suggesting that the interaction between metals was additive, and the level was decreased in the kidney after 2 and 16 days of exposure. The whole blood hemoglobin content (Hb), red blood cell count (RBCs) and mean corpuscular hemoglobin (MCH) differed from the control groups after 2 and 16 days of exposure, showing changes in the improvement of oxygen transport. The number of lymphocytes increased, and the levels of neutrophils, eosinophils, basophils and monocytes were reduced after exposure to the metals. The changes in blood cells suggested that tadpoles have a mechanism to improve oxygen transport probably because of the increased oxygen demand and a general reduction in defense cells. The exposure of L. catesbeianus to metals during the larval phase can generate long-term dysfunction to a degree, which could lead to alterations in their health status.

256

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Pollution - Volume 221, February 2017, Pages 445-452
نویسندگان
, , , , , ,