کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5759886 1623774 2018 22 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In silico modelling of apoptosis induced by photodynamic therapy
ترجمه فارسی عنوان
در مدل سازی سیلیکا از آپوپتوز ناشی از درمان فوتودینامیک
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی
Photodynamic therapy (PDT) is an emergent technique used for the treatment of several diseases. After PDT, cells die by necrosis, apoptosis or autophagy. Necrosis is produced immediately during photodynamic therapy by high concentration of reactive oxygen species, apoptosis and autophagy are triggered by mild or low doses of light and photosensitizer. In this work we model the cell response to low doses of PDT assuming a bi-dimensional matrix of interacting cells. For each cell of the matrix we simulate in detail, with the help of the Gillespie's algorithm, the two main chemical pathways leading to apoptosis. We unveil the role of both pathways in the cell death rate of the tumor, as well as the relevance of several molecules in the process. Our model suggests values of concentrations for several species of molecules to enhance the effectiveness of PDT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 436, 7 January 2018, Pages 8-17
نویسندگان
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