Exploring the effect of end-binding proteins and microtubule targeting chemotherapy drugs on microtubule dynamic instability

We further describe how EBs and MTAs alter MT dynamics. In the context of this modeling framework, we show that it is likely that MTAs and EBs do not work independently from one another. Thus, we propose a mechanism for how EBs can work synergistically with MTAs to promote MT dynamic instability at low MTA dose.