کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5763040 1625149 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro antiinflammatory and antioxidant potential of root extracts from Ranunculaceae species
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم زراعت و اصلاح نباتات
پیش نمایش صفحه اول مقاله
In vitro antiinflammatory and antioxidant potential of root extracts from Ranunculaceae species
چکیده انگلیسی
Among the ethanol extracts of roots of 25 Ranunculaceous plant species traditionally used in treatment of various inflammatory diseases, Helleborus purpurascens demonstrated the most promising inhibitory activity towards COX-1, COX-2 and 5-LOX enzymes (IC50 detected as 5.64, 10.33 and 3.84 μg/mL, respectively). GC-MS analysis of subfractions obtained from H. purpurascens extract revealed that a complex of fatty acids (especially α-linolenic acid) might be responsible for the observed antiinflammatory activity. The extract of Thalictrum minus was found to be selectively inhibiting COX-2 and 5-LOX enzymes (IC50 = 49.68 and 76.47 μg/mL, respectively) but had no inhibitory effect on COX-1 (IC50 > 128 μg/mL). Moreover, T. minus extract also showed significant antioxidant effect (DPPH = 0.074 g TE/g, and ORAC = 0.518 g TE/g) as well as was relatively rich on phenolic compounds (TPC = 0.352 g GAE/g). Statistical analysis showed that phenolic compounds might be only partially responsible for antioxidant potential demonstrated by this plant. The results of our study suggest that the above-mentioned members of Ranunculaceae family may possibly serve as a prospective material for further development of novel and safer plant-based antiinflammatory and/or antioxidant agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: South African Journal of Botany - Volume 109, March 2017, Pages 128-137
نویسندگان
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