کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5775573 | 1631740 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Co-dynamics of Pneumonia and Typhoid fever diseases with cost effective optimal control analysis
ترجمه فارسی عنوان
همبستگی داینامیک بیماری های پنومونی و بیماری های تب خونی با کنترل هزینه بهینه بهینه کنترل
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کلمات کلیدی
عفونت مشترک، ذات الریه، تب تیفوئید، کنترل بهینه، هزینه بهره وری، شبیه سازی عددی،
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
ریاضیات کاربردی
چکیده انگلیسی
In this paper, we propose and analyze a mathematical model for Pneumonia-Typhoid co-infection to examine their characteristic relationship due to preventive and treatments strategies. Firstly, we qualitatively analyzed the model, and the basic reproduction number is determined with respect to the existence and stability of equilibria. The possibility of bifurcation is studied and also we investigated the sensitivity index of co-infection model reproduction number together with the local and global stability of the equilibra. Secondly, we extend the co-infection model by incorporating time dependent controls as intervention and we used Pontryagin's maximum principle for derivation of necessary conditions for the optimal control and optimality system. Finally, the optimality system is numerically simulated by considering four strategies and also their cost effectiveness is analysed. We found that Pneumonia treatment with Typhoid fever prevention costs least. Therefore, for optimal cost effective control of both diseases, the policy makers must focus more on prevention strategy while treating the infected individual is not neglected.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Mathematics and Computation - Volume 316, 1 January 2018, Pages 438-459
Journal: Applied Mathematics and Computation - Volume 316, 1 January 2018, Pages 438-459
نویسندگان
Getachew Teshome Tilahun, Oluwole Daniel Makinde, David Malonza,