کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5798232 1111775 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficacy of a new topical cyclosporine A formulation in the treatment of atopic dermatitis in dogs
ترجمه فارسی عنوان
اثربخشی فرمول جدید سیکلوسپورین موضعی در درمان درماتیت آتوپیک در سگ ها
کلمات کلیدی
موضعی، سیکلوسپورین، سگ، درماتیت آتوپیک، کارازمایی بالینی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی

Topical treatment with cyclosporine A (CsA) has recently become possible with the development of novel nanotechnology pharmaceutical formulations of CsA able to penetrate through the epidermis providing good absorption and dermal action. The aim of this multicentre, blinded, parallel, randomized, placebo controlled trial was to evaluate the efficacy of a new topical CsA formulation in dogs with atopic dermatitis (AD). Dogs (n = 32) with severe and moderate clinical signs of non-seasonal AD, but few localized lesions, were randomly allocated to receive topical CsA (17 dogs) or placebo (15 dogs) and were treated twice a day for 6 weeks. Before and 21 and 45 days after starting the treatment, the severity of a previously selected skin lesion was evaluated according to a dermatological scoring system. Owners using a visual analogue scale also assessed pruritus weekly and effectiveness of the treatment was defined as a reduction of at least 50% in these variables after 45 days.After 21 and 45 days the lesion severity score in animals treated with CsA was significantly lower than at baseline (P < 0.01, both times). In contrast, the animals on placebo showed no significant improvement at days 21 or 45. The percentage of dogs with an effective reduction in pruritus at the end of the trial was 87.5% and 28.6% in the CsA and placebo groups, respectively. These results suggest that topical administration of CsA is effective in reducing the severity of skin lesions and pruritus in dogs with moderate to severe AD as soon as 3 weeks after starting treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 197, Issue 2, August 2013, Pages 280-285
نویسندگان
, , , , , , , ,