In vitro toxicity screening of chemical mixtures using HepG2/C3A cells

► HepG2/C3A cells were used to assess the cellular effects of three oil dispersants. ► The Corexit dispersants were significantly more cytotoxic than ZI-400. ► The dispersants increased levels of ROS and altered several cellular processes. ► DOSS made notable contributions to the cellular effects of the Corexit dispersants. ► This model may be a complementary tool for predicting toxicity of complex mixtures.