کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5874409 1144802 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review ArticleTroponin Elevation Predicts Atrial Fibrillation in Patients with Stroke or Transient Ischemic Attack
ترجمه فارسی عنوان
نقص مقاله: افزایش تروپونین پیش بینی می کند فیبریلاسیون دهلیزی در بیماران مبتلا به سکته مغزی یا حملات ایسکمیک گذرا
کلمات کلیدی
سکته حاد فیبریلاسیون دهلیزی، آمبول قلبی، تصادف مغزی-عروقی، حمله ایسکمی گذرا،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مغز و اعصاب بالینی
چکیده انگلیسی

BackgroundAtrial fibrillation (AF) is a major cause of ischemic stroke. Cardiac troponin (cTnI) is a marker of myocardial damage and may predict arrhythmia. We sought to determine if increased cTnI levels were a predictor of new-onset AF in ischemic stroke or patients with transient ischemic attack (TIA).MethodsConsecutive patients who presented to Charles-Lemoyne Hospital between October 2006 and November 2010 with a diagnosis of acute ischemic stroke or TIA, without a history of AF, with a baseline measurement of cTnI were included in the study. The primary outcome was new-onset AF on 24-hour Holter measurement within 1 week of admission in patients without AF on the baseline electrocardiogram (ECG). Secondary outcomes included AF on Holter measurement, death, myocardial infarction (MI), and stroke within 3 months.ResultsA total of 408 patients were included. Forty-six patients (11.3%) had elevated cTnI levels. These patients were older and had a higher prevalence of coronary artery disease and diabetes. AF on baseline ECG or 24-hour Holter measurement was present in 51 patients (12.5%) and was more frequent among patients with increased cTnI levels compared to patients with normal cTnI levels (34.7% vs 9.7%; P = .004 multivariate analysis). Elevated cTnI levels also predicted the composite outcome of stroke, MI, and death at 3 months (50.0% vs 16.1%; P = .0001).ConclusionscTnI elevation predicts new-onset AF on 24-hour Holter measurement in patients with acute ischemic stroke or TIA and may indicate a poorer prognosis and a higher risk of stroke, MI, and death at 3 months.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Stroke and Cerebrovascular Diseases - Volume 22, Issue 7, October 2013, Pages 978-983
نویسندگان
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