کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5943706 1574721 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of heart rate variability on C-reactive protein concentrations in Japanese adult nonsmokers: The Toon Health Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Impact of heart rate variability on C-reactive protein concentrations in Japanese adult nonsmokers: The Toon Health Study
چکیده انگلیسی


- We examined the association between HRV and inflammation among nonsmokers.
- Lowered SDNN, RMSSD, LF, and HF were significantly associated with elevated CRP.
- Parasympathetic dysfunction was connected with elevated inflammation.
- Association of HRV with inflammation was independent of insulin sensitivity.

ObjectiveLower heart rate variability (HRV) is associated with the inflammation that is linked with the progression of atherosclerosis. We examined this association, taking insulin sensitivity into consideration, as it is related to both HRV and inflammation.MethodsSubjects were 1728 individuals ages 30-79 years who did not smoke between 2009 and 2012. C-reactive protein (CRP) concentrations and white blood cell (WBC) counts were assessed as markers of inflammation. The homeostasis model assessment index for insulin resistance (HOMA-IR) and Gutt's insulin sensitivity index (ISI) were calculated based on fasting and 2h-post-load glucose and insulin concentrations in a 75-g oral glucose tolerance test. Pulse was recorded for 5 min, and time-domain HRV indices of standard deviation of NN intervals (SDNN) and root mean square of successive differences (RMSSD) were calculated. Power spectral analysis provided frequency domain measures of HRV: high frequency (HF) power, low frequency (LF) power and LF/HF.ResultsSex and age-adjusted logistic models presented quartiles of SDNN, RMSSD, LF, and HF significantly associated with the highest quartile of CRP or WBC. After adjustment for body mass index and ISI, the associations were attenuated for WBC; however, even after further adjustment for several variables, SDNN, RMSSD, LF, and HF remained significantly associated with elevated CRP concentrations. When results were stratified by weight, the associations appeared more evident among non-overweight individuals.ConclusionLowered HRV, primarily due to parasympathetic dysfunction, was associated with elevated inflammation, independent of weight, insulin sensitivity, and other related factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 244, January 2016, Pages 79-85
نویسندگان
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