کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
6000422 1579200 2016 3 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Lack of association of plasma gamma prime (γ′) fibrinogen with incident cardiovascular disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Lack of association of plasma gamma prime (γ′) fibrinogen with incident cardiovascular disease
چکیده انگلیسی


- The relation of gamma prime (γ′) fibrinogen with cardiovascular disease (CVD) remains equivocal.
- Prospective associations of γ′ fibrinogen with CVD are limited.
- We failed to show associations between γ′ fibrinogen and CVD endpoints beyond CVD risk factors.

IntroductionThe association of gamma prime (γ′) fibrinogen; a fibrinogen γ chain variant generated via alternative mRNA processing, with cardiovascular disease (CVD) remains equivocal. We prospectively examine the association of plasma γ′ fibrinogen with the incidence of multiple cardiovascular disease (CVD) endpoints, independent of established CVD risk factors and total fibrinogen.Materials and methodsWe measured plasma γ′ fibrinogen on plasma samples collected in 1992-1993 from adults ≥ 65 years (n = 3219) enrolled in the Cardiovascular Health Study, who were followed through 2013 for incident CVD events.Results and conclusionsIn multivariable Cox models adjusted for traditional CVD risk factors and total fibrinogen, the hazard ratio per 1 standard deviation (10.7 mg/dl) increment of γ′ fibrinogen was 1.02 (95%CI: 0.95-1.10) for coronary heart disease; 0.88 (0.77-1.00) for ischemic stroke; 1.07 (0.87-1.32) for peripheral artery disease; 1.00 (0.92-1.08) for heart failure and 1.01 (0.92-1.10) for CVD mortality. Likewise, we failed to show a statistically significant association of γ′/total fibrinogen ratio with any CVD endpoint. These results suggest that among the elderly, γ′ fibrinogen does not add much to CVD prediction beyond traditional risk factors and total fibrinogen level.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 143, July 2016, Pages 50-52
نویسندگان
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