کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6003918 1579522 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Skeletal muscle electrical stimulation improves baroreflex sensitivity and heart rate variability in heart failure rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Skeletal muscle electrical stimulation improves baroreflex sensitivity and heart rate variability in heart failure rats
چکیده انگلیسی


- Electrical stimulation (ES) decreases the sympatho-vagal balance in heart failure.
- ES enhances heart rate parasympathetic modulation in heart failure (CHF) animals.
- A long term ES protocol in CHF animals improves the arterial baroreflex sensitivity.
- 4-week ES protocol in CHF rats improves the cardiovascular autonomic control.

The goal of the current study was to evaluate the effects of electrical stimulation (ES) on the arterial baroreflex sensitivity (BRS) and cardiovascular autonomic control in rats with chronic heart failure (CHF). Male Wistar rats were designated to one of four groups: placebo sham (P-Sham, n = 9), ES sham (ES-Sham, n = 9), placebo CHF (P-CHF, n = 9) or ES CHF (ES-CHF, n = 9). The ES was adjusted at a low frequency (30 Hz), duration of 250 μs, with hold and rest time of 8 s (4 weeks, 30 min/day, 5 times/week). It was applied on the gastrocnemius muscle with intensity to produce a visible muscle contraction. The rats assigned to the placebo groups performed the same procedures with the equipment turned off. The two-way ANOVA and the post hoc Student-Newman-Keuls tests (P < 0.05) were used to data comparison. The BRS was higher in ES-Sham group compared to the P-Sham group and the ES-CHF group compared to the P-CHF group. ES was able to decrease heart rate sympatho-vagal modulation and peripheral sympathetic modulation in ES-CHF compared to P-CHF group. Interestingly, heart rate sympatho-vagal modulation was similar between ES-CHF and P-Sham groups. Thus, ES enhances heart rate parasympathetic modulation on heart failure (ES-CHF) compared to placebo (P-CHF), with consequent decrease of sympatho-vagal balance in the ES-CHF group compared to the P-CHF. The results show that a 4 week ES protocol in CHF rats enhances arterial BRS and cardiovascular autonomic control.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 193, December 2015, Pages 92-96
نویسندگان
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