کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6064712 | 1201864 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Advances in basic and clinical immunology in 2014
ترجمه فارسی عنوان
پیشرفت در ایمنی اولیه و بالینی در سال 2014
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کلمات کلیدی
PAPRAGHIV1GvHDCVIDNF-κBWESHSCTDOCK8CGDNLRC4TregSCIDMSDMucosa-associated lymphoid tissue lymphoma translocation protein 1URDTCrMALT1BCL10PIDTCTLRnatural killer - (سلول های) کشنده طبیعیadenosine deaminase - آدنوزین دآمینازSTAT - آمارenzyme replacement therapy - آنزیم جایگزین درمانApoe - آپوapolipoprotein E - آپولیپوپروتئین EMatched unrelated donor - اهداکننده مرتبط با یکپارچهMatched sibling donor - اهداکننده همکار با همسرImmunology - ایمونولوژیIntravenous immunoglobulin - اﯾﻤﻮﻧﻮﮔﻠﻮﺑﻮﻟﯿﻦ ورﯾﺪیGraft-versus-host disease - بیماری مرض در برابر میزبانchronic granulomatous disease - بیماری گرانولوماتوز مزمنWhole-exome sequencing - توالی کامل exomeToll-like receptor - تیالآرcaspase recruitment domain - دامنه استخدام کاسپسplasma cell - سلول پلاسماNewborn screening - غربالگری نوزادانnuclear factor κB - فاکتور هسته ای κBSignal transducer and activator of transcription - مبدل سیگنال و فعال کننده رونویسیDedicator of cytokinesis 8 - متخصص سیتوکینزی 8Regulatory T - مقررات TCVID, common variable immunodeficiency - نقص ایمنی متغیر شایعSCID, Severe combined immunodeficiency - نقص ایمنی مرکب شدیدERT - هستندADA - وجود داردPulmonary alveolar proteinosis - پروتئینوز آلوئولار ریهHematopoietic stem cell transplantation - پیوند مغز استخوانRecombination-Activating Gene - ژن فعال سازی مجدد ترکیبRecombination-activating gene 1 - ژن فعال سازی مجدد ترکیب 1CARD - کارتprimary immunodeficiency - کمبود ایمنی اولیهT-cell receptor - گیرنده لنفوسیت T
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Genetic identification of immunodeficiency syndromes has become more efficient with the availability of whole-exome sequencing, expediting the identification of relevant genes and complementing traditional linkage analysis and homozygosity mapping. New genes defects causing immunodeficiency include phophoglucomutase 3 (PGM3), cytidine 5Ⲡtriphosphate synthase 1 (CTPS1), nuclear factor κB-inducing kinase (NIK), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10), phosphoinositide-3 kinase regulatory subunit 1 (PIK3R1), IL21, and Jagunal homolog 1 (JAGN1). New case reports expanded the clinical spectrum of gene defects. For example, a specific recombination-activating gene 1 variant protein with partial recombinant activity might produce Omenn syndrome or a common variable immunodeficiency phenotype. Central and peripheral B-cell tolerance was investigated in patients with several primary immunodeficiencies, including common variable immunodeficiency and Wiskott-Aldrich syndrome, to explain the occurrence of autoimmunity and inflammatory disorders. The role of IL-12 and IL-15 in the enhancement of natural killer cell activity was reported. Newborn screening for T-cell deficiency is being implemented in more states and is achieving its goal of defining the true incidence of severe combined immunodeficiency and providing early treatment that offers the highest survival for these patients. Definitive treatment of severe immunodeficiency with both hematopoietic stem cell transplantation and gene therapy was reported to be successful, with increasing definition of conditions needed for optimal outcomes. Progress in HIV infection is directed toward the development of an effective vaccine and the eradication of hidden latent virus reservoirs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 135, Issue 5, May 2015, Pages 1132-1141
Journal: Journal of Allergy and Clinical Immunology - Volume 135, Issue 5, May 2015, Pages 1132-1141
نویسندگان
Javier MD, PhD, Luigi D. MD, William T. MD, PhD,