کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6089102 | 1589666 | 2016 | 6 صفحه PDF | دانلود رایگان |
- Adiposity was associated with reduced bone mass in the early phases of inflammatory bowel disease (IBD), but with increased bone mass in the controls.
- Bone mass did not differ between the normal-weight IBD subjects and normal-weight controls in the early phases of IBD in children and adolescents.
- Bone mass was lower in children and adolescents with Crohn's disease compared to those with ulcerative colitis.
ObjectivesThe effect of adiposity on bone mass in the early phases of inflammatory bowel disease (IBD) in children and adolescents is unclear. The aim of this study was to determine the role of adiposity on bone mass in the first 3 y of diagnosis of IBD. The expected result is that increased adiposity will be associated with increased bone mass in both the controls and IBD subjects.MethodsHeight-adjusted bone mineral density (BMD) z-scores of 25 subjects, age 13.97 ± 2.70 y, diagnosed with IBD for <4 y were compared to 24 controls, age 13.65 ± 2.60 y. Overweight was defined as BMI of â¥85th but <95th percentile, and obesity as BMI â¥95th percentile. Severity of IBD was determined by the Pediatric Crohn's Disease Activity Index and Lichtiger Colitis Activity Index.ResultsBefore stratification by BMI criterion, height-adjusted BMD z-scores were not significantly lower in IBD subjects versus controls for both the femoral neck (â0.8 ± 1.1 versus â0.06 ± 1.1, P = 0.070) and lumbar vertebrae (â0.4 ± 1.2 versus 0.2 ± 1.2, P = 0.086). Following stratification, height-adjusted BMD z-scores were significantly lower in the overweight/obese IBD subjects versus overweight/obese controls for femoral neck (â0.9 ± 0.9 versus 0.3 ± 1.3, P = 0.032); and non-significantly lower for the lumbar spine z-score (â0.4 ± 1.6 versus 0.5 ± 1.3, P = 0.197). BMD z-score had no relationship with the duration of disease, steroid therapy, and the severity of disease.ConclusionAdiposity was associated with reduced bone mass in the early phases of IBD, but with increased bone mass in the controls.
Journal: Nutrition - Volume 32, Issues 7â8, JulyâAugust 2016, Pages 761-766