کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6092782 1209782 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewGenomicsGenetics and Molecular Pathogenesis of Gastric Adenocarcinoma
ترجمه فارسی عنوان
ژنومیکس ژنتیک و پاتوژنز مولکولی آدنوکارسینومای معده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی

Gastric cancer (GC) is globally the fifth most common cancer and third leading cause of cancer death. A complex disease arising from the interaction of environmental and host-associated factors, key contributors to GC's high mortality include its silent nature, late clinical presentation, and underlying biological and genetic heterogeneity. Achieving a detailed molecular understanding of the various genomic aberrations associated with GC will be critical to improving patient outcomes. The recent years has seen considerable progress in deciphering the genomic landscape of GC, identifying new molecular components such as ARID1A and RHOA, cellular pathways, and tissue populations associated with gastric malignancy and progression. The Cancer Genome Atlas (TCGA) project is a landmark in the molecular characterization of GC. Key challenges for the future will involve the translation of these molecular findings to clinical utility, by enabling novel strategies for early GC detection, and precision therapies for individual GC patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 149, Issue 5, October 2015, Pages 1153-1162.e3
نویسندگان
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