کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6121934 1219189 2016 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Whole-genome sequencing as standard practice for the analysis of clonality in outbreaks of meticillin-resistant Staphylococcus aureus in a paediatric setting
ترجمه فارسی عنوان
توالی کامل ژنوم به عنوان عمل استاندارد برای تجزیه و تحلیل کلونی بودن در شیوع استافیلوکوک اورئوس مقاوم به متیسیلین در محیط اطفال
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
Meticillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of hospital-associated infections. This study investigated the potential use of whole-genome sequencing (WGS) for surveillance purposes by re-examining MRSA strains related to past outbreaks among hospitalized paediatric patients. WGS data ameliorated the genotypic profile previously obtained with Sanger sequencing and pulsed-field gel electrophoresis typing, and discriminated between strains that were related and unrelated to the outbreaks. This allowed strain clonality to be defined with a higher level of resolution than achieved previously. This study demonstrates the potential of WGS to trace hospital outbreaks, which may lead to WGS becoming standard practice in outbreak investigations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hospital Infection - Volume 93, Issue 4, August 2016, Pages 375-381
نویسندگان
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