The use of novel technology-based weight loss interventions for obese women with endometrial hyperplasia and cancer

- Obese EC survivors are interested in technology-based weight loss interventions
- Obese EC survivors lost weight in 6-month weight loss interventions with telemedicine and text messaging modalities
- Levels of IL-2 decreased after weight loss

ObjectiveObesity significantly increases the risk of the development of both endometrial hyperplasia and cancer. Our objective was to assess the feasibility of two technology-based weight loss interventions in this patient population.MethodsWomen with obesity (BMI ≥ 30 kg/m2) and endometrial hyperplasia or Type I endometrial cancer were randomized 1:1 to a technology-based 6 month lifestyle intervention via either telemedicine or text messaging. The telemedicine arm received weekly phone calls, with weights tracked online using Withings© Wi-Fi scales. The text arm received 3-5 personalized messages daily via Text4Diet™. Participants maintained a 1200-1800 calorie/day diet, self-monitored food intake and received exercise goals. Biomarkers (IGFBP-1, adiponectin, VEGF, IL1-beta, IL2, IL6, and IL7) were assessed pre- and post-treatment.ResultsTwenty women were randomized (Telemedicine: n = 10, Text4Diet: n = 10), and 90% lost weight. Many were early stage (70%) and grade (43.8%) disease with a median age of 60.5 years. We observed a statistically greater weight loss in the Telemedicine arm [median loss: 9.7 kg (range: 1.6-22.9 kg)] versus 3.9 kg (range: 0.3-11.4 kg) in the Text4Diet arm (p = 0.0231). Similarly, percent weight loss was greater in the Telemedicine (7.6%) as compared to the Text4Diet arm (4.1%, p = 0.014). Mean serum levels of IL-2 were significantly (27.15 pg/mL vs. 5.18 pg/mL, p = 0.0495) lower at intervention end as compared to baseline.ConclusionsA technology-based weight loss intervention is feasible in women with Type I endometrial cancer/hyperplasia. Both interventions produced weight loss, although more person-to-person contact produced more significant outcomes. Reductions in expression of IL-2 were related to weight loss.