کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6196258 1602575 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Resident corneal c-fms+ macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
پیش نمایش صفحه اول مقاله
Resident corneal c-fms+ macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis
چکیده انگلیسی


- Resident corneal myeloid derived cells recruit leukocytes early in adenovirus keratitis.
- Adenovirus keratitis is diminished in dendritic and macrophage ablated MaFIA mice.
- Both keratocytes and myeloid lineage cells in the corneal stroma play critical roles in the early innate immune responses to adenovirus corneal infection.

The cornea contains a heterogeneous population of antigen-presenting cells with the capacity to contribute to immune responses. Adenovirus keratitis is a severe corneal infection with acute and chronic phases. The role of resident corneal antigen-presenting cells in adenovirus keratitis has not been studied. We utilized transgenic MaFIA mice in which c-fms expressing macrophages and dendritic cells can be induced to undergo apoptosis, in a mouse model of adenovirus keratitis. Clinical keratitis and recruitment of myeloperoxidase and CD45+ cells were diminished in c-fms depleted, adenovirus infected mice, as compared to controls, consistent with a role for myeloid-lineage cells in adenovirus keratitis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 147, June 2016, Pages 144-147
نویسندگان
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