کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6250274 1611480 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical ScienceFirst and repeat liver resection for primary and recurrent intrahepatic cholangiocarcinoma
ترجمه فارسی عنوان
علم بالینی و اولین تکه شدن کبد برای کلانژیوکارسینوم داخل کبدی اولیه و مکرر است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی


- Recurrence after resection of intrahepatic cholangiocarcinoma (ICC) is common.
- Recent studies showed that cure after resection of ICC seems to be an elusive goal.
- Tumor size greater than 5 cm is an independent risk factor for recurrence.
- Recurrence after resection of ICC is often beyond the limits of resectability.
- A repeat liver resection (RLR) was feasible in only 25% of patients.
- A RLR was associated with prolonged overall survival.

BackgroundRecurrence after resection of intrahepatic cholangiocarcinoma (ICC) remains common. The present study sought to evaluate risk factors for recurrence and the results of repeat liver resection (RLR) for recurrent ICC.MethodsBetween 1997 and 2012, clinical data and outcomes of 125 consecutive patients undergoing liver resection for ICC were retrospectively analyzed.ResultsThe rate of R0 resection was 89% (n = 110). Overall median survival was 35 months, and 1-, 3-, and 5-year actuarial survival rates were 80%, 48%, and 28%, respectively. Recurrence occurred in 76 patients (63.5%) and was intrahepatic only for 39 patients (51%). Tumor size greater than 5 cm was identified as an independent risk factor for recurrence (P ≤ .0001). RLR for recurrent ICC was feasible in 10 patients (25%) with a median survival after recurrence of 25 months (16 to 76).ConclusionsTumor size more than 5 cm represents an independent risk factor for recurrence after resection of ICC. RLR in case of recurrent ICC, when feasible, is associated with longer overall survival.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Surgery - Volume 212, Issue 2, August 2016, Pages 221-229
نویسندگان
, , , , , , , , , , , ,